January 8 – The China Clipper, a Pan Am Martin M-130 flying boat operating as Flight 161, crashes in Port of Spain, Trinidad, killing all 25 on board.
January 31 – The Stinson Tokana operated by Australian National Airways crashes, killing all 10 on board. The accident was caused by a fatigue crack in a wing spar.
July 12 – Eastern Air Lines Flight 45, a Douglas DC-3A, collides with a Douglas A-26 Invader over Florence, South Carolina, United States. One of the 24 on the DC-3 and 1 of the 2 on the A-26 die.
October 5 – National Airlines Flight 16, a Lockheed L-18 Lodestar, overshoots the runway at Lakeland, Florida, United States, killing 2 of 15 on board.
November 3 – The prototype Boeing 314, named the Honolulu Clipper, makes an emergency landing in the Pacific 650 miles east of Oahu due to double engine failure; the aircraft is intentionally sunk after salvage was deemed impractical; all 26 passengers on