April 25 – Cubana de Aviación Flight 493, a Douglas DC-4 en route from Miami to Havana, collides in mid-air with a United States Navy Beech SNB-1 Kansan off Key West; all 43 aboard both aircraft are killed.
June 22 – Pan Am Flight 151, a Lockheed L-049 Constellation en route from Accra, Ghana (then the Gold Coast Territory) to Monrovia, Liberia, crashes into a hill near Sanoye in Bong County, Liberia, 54 miles (86 km) from the airport; all 31 passengers and 6 crew members die.
June 30 – United Airlines Flight 610, a Douglas DC-6, flies into a mountain in Larimer County, Colorado, due to a navigational error; all 45 passengers and 5 crew members are killed.
July 21 – A Canadian Pacific Air Lines Douglas DC-4 disappears on a flight from Vancouver, British Columbia, Canada, to Tokyo, Japan; all 37 on board are presumed dead; the aircraft has never been found.
August 24 – United Airlines Flight 615, a Douglas DC-6B, crashes near Decoto (now Union City, California), while on final approach to Oakland, California; all 44 passengers and 6 crew members die.
November 15 – A LOT Polish Airlines Lisunov Li-2 crashes near Tuszyn shortly after takeoff due to engine failure, killing all 16 passengers and crew on board.
December 16 – A Miami Airlines Curtiss C-46 Commando crashes at Elizabeth, New Jersey, after a loss of control following an engine fire, killing all 56 passengers and crew on board.
December 22 – A Misrair SNCASE Languedoc crashes west of Tehran, killing all 20 people on board.
December 29 – Continental Charters Flight 44-2, a Curtiss-Wright C-46, crashes into a ridge near Napoli, New York, while en route to Buffalo, New York; 3 crew members and 23 passengers die.