January 12 – TWA Flight 694, a Martin 2-0-2, collides with a privately owned Douglas DC-3 over Cincinnati, Ohio, killing all 15 on board both aircraft.
February 19 – TWA Flight 260, a Martin 4-0-4, crashes into the Sandia Mountains near Albuquerque, New Mexico, killing all 16 on board.
March 26 – Pan Am Flight 845/26, a Boeing 377, ditches into the Pacific Ocean off the Oregon coast, killing four of the 23 on board.
April 4 – A United Airlines Douglas DC-6 crashes after takeoff from Long Island MacArthur Airport, New York, killing all 3 on board.
April 11 – An Air India Lockheed L-749 Constellation named Kashmir Princess explodes under suspicious circumstances; 16 people are killed and three survive.
July 27 – El Al Flight 402, a Lockheed L-049 Constellation, inadvertently strays over Bulgarian territory on its way from Vienna to Tel Aviv, and is shot down by two Bulgarian fighter aircraft, killing all 58 on board.
October 6 – United Airlines Flight 409, a Douglas DC-4, crashes into Medicine Bow Peak near Centennial, Wyoming, killing all 66 on board.
November 1 – United Airlines Flight 629, a Douglas DC-6B, is bombed by Jack Gilbert Graham over Longmont, Colorado; all 44 on board are killed.